A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer

First Author / 第一作者

Shih-Hsin Tu(1,2,3)

Institution / 單位

Audio / 音訊檔

Author Group / 作者群

Hui-Wen Chiu(4,5), Ya-Ling Yeh(6), Sheng-Yow Ho(7,8), Yuan-Hua Wu(9,10), Bour-Jr Wang(11,12), Wei-Jan Huang(13), Ying-Jan Wang(14), Li-Ching Chen(1,2,15), Yuan-Soon Ho(15,16,17,18)

Author Group Institution/ 作者群單位

(1)Division of Breast Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan; (2)Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; (3)Department of Surgery, School of Medicine, Clooege of Medicine, Taipei Medical University, Taipei, Taiwan; (4)Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei Taiwan; (5)Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; (6)Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan; (7)Department of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan; (8)Graduate Institute of Medical Sciences, Chang Jung Christian University, Tainan, Taiwan; (9)Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan; (10)Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; (11)Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; (12)Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; (13)Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan; (14)Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan; (15)TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan; (16)Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; (17)Department of Laboratory Medicine, Taipei Medical University Hospital, Taipei, Taiwan; (18)School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

Category / 主題分類

Basic Research

Keyword / 關鍵字

histone deacetylase inhibitor、aggresome、radiation、autophagy、triple-negative breast cancer

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